1. From the Keenan Research Centre for Biomedical Science, St. Michael’s Hospital, Toronto, Canada (M.J.M., J.W.S., W.M.K); Departments of Physiology and Anesthesia (M.J.M.), Pharmacology (J.W.S.), Laboratory Medicine–Pathobiology (C.C.-G.), Medicine–Division of Hematology (C.C.-G.), Anesthesia and Pain Management, University Health Network (K.K.), and Physiology and Surgery (W.M.K.), University of