Cancer cachexia – adopting a systems wide approach

Author:

Sayers Judith123,Skipworth Richard JE.3,Laird Barry JA.12

Affiliation:

1. St Columba's Hospice

2. Institute of Genetics and Cancer, University of Edinburgh

3. Clinical Surgery University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK

Abstract

Purpose of review Cancer cachexia results in the death of approximately 2 million people worldwide annually. Despite the impact of this devastating condition, there is limited therapy and no standard of care. Although multiple definitions exist, confusion remains as a true understanding of the biology has not yet been achieved and distinct phases of cachexia have not been examined. Research has mainly focused on weight loss and muscle wasting, but cachexia is increasingly recognized as a multiorgan disorder involving adipose tissue, liver, brain, gut and heart, with systemic inflammation a central unifying feature. Recent findings In this review, we will discuss some of the extra-muscular features and multisystem interactions in cachexia, and describe how moving our focus beyond muscle can lead to a greater understanding of the mechanisms and clinical features seen in cachexia. Summary We describe the need for robust characterization of patients with cachexia, to allow clinical phenotypes and multisystem mechanisms to be untangled, and to enable the implementation of multimodal treatment strategies.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Nutrition and Dietetics,Medicine (miscellaneous)

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Central neural mechanisms of cancer cachexia;Current Opinion in Supportive & Palliative Care;2024-05-15

2. La cachexie associée au cancer;médecine/sciences;2024-04

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