Granulomatous Panniculitis as an Initial Manifestation of Sjögren Syndrome-Reference-Cited by-同舟云学术

Granulomatous Panniculitis as an Initial Manifestation of Sjögren Syndrome

Published:2024-06-06 Issue: Volume: Page:
ISSN:0193-1091
Container-title:The American Journal of Dermatopathology
language:en
Short-container-title:

Author:

Méndez-Flores Silvia¹^ORCID,Méndez-Pérez R. Angélica¹,Saeb-Lima Marcela²,Hernández-Molina Gabriela³

Affiliation:

1. Dermatology Department, National Institute of Medical Sciences and Nutrition “Salvador Zubiran”, Mexico City, Mexico;

2. Pathology Department, National Institute of Medical Sciences and Nutrition “Salvador Zubiran” Mexico City, Mexico; and

3. Rheumatology and Immunology Department, National Institute of Medical Sciences and Nutrition “Salvador Zubirán", Mexico City, Mexico.

Abstract

Abstract: A 65-year-old woman presented with unexplained weight loss, recurrent fever, and a dermatosis with painful nodules on the extremities. Biopsies showed focal lobular panniculitis with neutrophilic microgranulomas. Comprehensive investigations ruled out infection and hematologic and solid organ neoplasms. Laboratory results showed anti-Ro/SSA and anti-La/SSB antibody positivity, and elevated inflammatory markers. Dry mouth and eye were confirmed. The diagnosis of Sjögren syndrome with cutaneous panniculitis was established. Prednisone treatment with 30 mg/d resulted in remission of fever and pain improvement. This case emphasizes Sjögren syndrome as an autoimmune disease with multiple cutaneous manifestations and highlights its association with granulomatous panniculitis.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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