HIV medical care interruption among people living with HIV in Spain, 2004–2020

Author:

Izquierdo Rebeca12,Rava Marta12,Moreno-García Estela3,Blanco José Ramón4,Asensi Víctor5,Cervero Miguel6,Curran Adrian7,Rubio Rafael8,Iribarren José Antonio9,Jarrín Inmaculada12

Affiliation:

1. National Center for Epidemiology, Instituto de Salud Carlos III

2. Centre of Biomedical Research for Infectious Diseases (CIBERINFEC), Madrid

3. Infectious Diseases Department, Hospital Universitario de Navarra, Pamplona

4. Infectious Diseases Department, Hospital San Pedro-CIBIR, Logroño

5. Infectious Diseases - HIV Unit, Internal Medicine, Hospital Universitario Central de Asturias, Oviedo University School of Medicine, Translational Research in Infective Pathology Lab, ISPA-FINBA

6. Internal Medicine Department, Hospital Universitario Severo Ochoa, Leganés

7. Infectious Diseases Department, Vall d’Hebron University Hospital, Vall d’Hebron Research Institute, Barcelona

8. HIV Unit, Internal Medicine Department, Biomedical Research Institute Imas12, Hospital Universitario 12 de Octubre. Medicine Department. Universidad Complutense de Madrid, Madrid

9. Department of Infectious Diseases, Donostia University Hospital, IIS Biodonostia, San Sebastián, Spain.

Abstract

Objective: We estimated the incidence rate of HIV medical care interruption (MCI) and its evolution over a 16-year-period, and identified associated risk factors among HIV-positive individuals from the Cohort of the Spanish AIDS Research Network in 2004–2020. Design: We included antiretroviral-naive individuals aged at least 18 years at enrolment, recruited between January 1, 2004, and August 30, 2019, and followed-up until November 30, 2020. Methods: Individuals with any time interval of at least 15 months between two visits were defined as having a MCI. We calculated the incidence rate (IR) of having at least one MCI and used multivariable Poisson regression models to identify associated risk factors. Results: Of 15 274 individuals, 5481 (35.9%) had at least one MCI. Of those, 2536 (46.3%) returned to HIV care after MCI and 3753 (68.5%) were lost to follow-up at the end of the study period. The incidence rate (IR) of MCI was 7.2/100 person-years (py) [95% confidence interval (CI): 7.0–7.4]. The annual IR gradually decreased from 20.5/100 py (95% CI: 16.4–25.6) in 2004 to 4.9/100 py (95% CI: 4.4–5.5) in 2014, a slight increase was observed between 2015 and 2018, reaching 9.3/100 py (95% CI: 8.6–10.2) in 2019. Risk factors for MCI included younger age, lower educational level, having contracted HIV infection through injecting drug use or heterosexual intercourse, having been born outside of Spain, and CD4+ cell count >200 cell/μl, viral load <100 000 and co-infection with hepatitis C virus at enrolment. Conclusions: Around a third of individuals had at least one MCI during the follow-up. Identified predictors of MCI can help health workers to target and support most vulnerable individuals.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Infectious Diseases,Immunology,Immunology and Allergy

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3