The impact of obesity on doravirine exposure in people with HIV-Reference-Cited by-同舟云学术

The impact of obesity on doravirine exposure in people with HIV

Published:2023-12-20 Issue:2 Volume:38 Page:267-269
ISSN:0269-9370
Container-title:AIDS
language:en
Short-container-title:

Author:

Zino Leena¹,van Bussel Lianne P.M.¹,Greupink Rick¹,Marneef Manon²,Burger David M.¹,Colbers Angela¹

Affiliation:

1. Department of Pharmacy

2. Department of Internal Medicine, Radboudumc Research Institute for Medical Innovation (RIMI), Radboud University Medical Center, Nijmegen, the Netherlands.

Abstract

Obesity incidence is increasing among people with HIV. Doravirine is a recommended first-line antiretroviral drug in many countries with no data from people with obesity. This study investigates the exposure of doravirine 100 mg standard dose in obese versus normal weight patients using clinical data combined with physiologically based pharmacokinetic modelling. Results from both approaches showed an elevated doravirine exposure during obesity, yet within the safety range of doravirine with no need for dose modification.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Infectious Diseases,Immunology,Immunology and Allergy

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