A Discordant Pattern of Uptake on 68Ga-PSMA PET/CT Versus 18F-Fluciclovine PET/CT in Radiation-Induced Hepatitis-Reference-Cited by-同舟云学术

A Discordant Pattern of Uptake on 68Ga-PSMA PET/CT Versus 18F-Fluciclovine PET/CT in Radiation-Induced Hepatitis

Published:2023-01-14 Issue:4 Volume:48 Page:e202-e203
ISSN:1536-0229
Container-title:Clinical Nuclear Medicine
language:en
Short-container-title:Clin Nucl Med

Author:

Adediran Omotayo A.¹,Lawal Ismaheel O.,Muzahir Saima¹,Bhave Manali A.²,Friend Sarah²,Fielder Bridget¹,Meisel Jane²,Torres Mylin A.³,Styblo Toncred M.⁴,Graham Cathy⁴,Holbrook Anna¹,Kalinsky Kevin²,Crowe Ronald J.⁵,Ulaner Gary A.⁶,Schuster David M.¹

Affiliation:

1. Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA

2. Department of Hematology and Medical Oncology, Emory University, Atlanta, GA

3. Department of Radiation Oncology, Emory University, Atlanta, GA

4. Department of Surgery, Emory University, Atlanta, GA

5. Emory Centre for Systems Imaging Core, Emory University, Atlanta, GA

6. Molecular Imaging and Therapy, Hoag Family Cancer Institute, Newport Beach, CA.

Abstract

Abstract A 62-year-old woman with right-sided invasive lobular breast carcinoma completed external beam radiotherapy 6 weeks before undergoing a 68Ga-PSMA PET/CT and 18F-fluciclovine PET/CT scan as part of an ongoing clinical trial (NCT04750473) assessing the performance of these molecular imaging modalities in invasive lobular breast carcinoma. The 68Ga-PSMA PET/CT demonstrated a band-like area of increased radiotracer uptake in the dome of the right lobe of the liver anteriorly, whereas 18F-fluciclovine PET/CT done a day later revealed photopenia in the corresponding area of the liver. The external beam radiotherapy plan confirmed that the radiotherapy field overlaid the region of the hepatic discordant radiotracer uptake on the PET/CT scans.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Radiology, Nuclear Medicine and imaging,General Medicine

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