Hepatic PSMA-Avid Postradiation Inflammation

Abstract

Abstract A 62-year-old man with de novo large volume metastatic prostate cancer to the bone, liver, and nodes status post multiple lines of therapy including external beam radiation to T12–L2 approximately 13 months prior underwent 68Ga-PSMA PET/CT to determine eligibility for 177Lu-PSMA therapy. 68Ga-PSMA PET/CT demonstrated tracer-avid osseous and nodal lesions consistent with metastases. In addition, regional geographic tracer avidity was seen in the midline left hepatic lobe associated with capsular retraction and demonstrated no FDG avidity on subsequent imaging, probably inflammatory related to prior radiation to T12–L2.