Early development history of Botox (onabotulinumtoxinA)

Author:

Scott Alan B.1,Honeychurch Dennis2,Brin Mitchell F.34

Affiliation:

1. Strabismus Research Foundation, San Francisco, CA, USAdeceased

2. US Naval Hospital Oakland, CA, USAretired

3. Allergan/AbbVie, Irvine, CA, USA

4. University of California, Irvine, CA, USA

Abstract

The development of Botox (onabotulinumtoxinA) began in the 1970s as Dr. Scott was attempting to identify an injectable substance that would weaken the extraocular eye muscles in patients with strabismus as an alternative to muscle surgery. This search led to botulinum toxin type A, which was tested and developed over the next 15 years. As botulinum toxin type A moved from an experimental drug to a product in need of licensing by the Food and Drug Administration (FDA), the first manufacturing methods and quality control procedures were developed for Oculinum, the botulinum toxin type A product that would eventually be sold to Allergan and become known as Botox.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

General Medicine

Reference15 articles.

1. Pharmacologic weakening of extraocular muscles.;Scott;Invest Ophthalmol,1973

2. Botulinum toxin injection into extraocular muscles as an alternative to strabismus surgery.;Scott;Ophthalmology,1980

3. Botulinum toxin injection of eye muscles to correct strabismus.;Scott;Trans Am Ophthalmol Soc,1981

4. Localized injections of botulinum toxin for the treatment of focal dystonia and hemifacial spasm.;Brin;Mov Disord,1987

5. Double-blind study of botulinum toxin in spasmodic torticollis.;Tsui;Lancet,1986

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