Germline Predisposition to Myelodysplastic Syndromes

Author:

Gener-Ricos Georgina1,Gerstein Yoheved S.2,Hammond Danielle1,DiNardo Courtney D.1

Affiliation:

1. Department of Leukemia

2. Clinical Cancer Genetics Program, The University of Texas MD Anderson Cancer Center, Houston, TX.

Abstract

AbstractWhile germline predisposition to myelodysplastic syndromes is well-established, knowledge has advanced rapidly resulting in more cases of inherited hematologic malignancies being identified. Understanding the biological features and main clinical manifestations of hereditary hematologic malignancies is essential to recognizing and referring patients with myelodysplastic syndrome, who may underlie inherited predisposition, for appropriate genetic evaluation. Importance lies in individualized genetic counseling along with informed treatment decisions, especially with regard to hematopoietic stem cell transplant–related donor selection. Future studies will improve comprehension of these disorders, enabling better management of affected patients and their families.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cancer Research,Oncology

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