Fibroblast growth factor receptor 3 activates a network of profibrotic signaling pathways to promote fibrosis in systemic sclerosis

Author:

Chakraborty Debomita1ORCID,Zhu Honglin12ORCID,Jüngel Astrid3ORCID,Summa Lena1,Li Yi-Nan1ORCID,Matei Alexandru-Emil1ORCID,Zhou Xiang1,Huang Jingang1,Trinh-Minh Thuong1,Chen Chih-Wei1ORCID,Lafyatis Robert4ORCID,Dees Clara1,Bergmann Christina1ORCID,Soare Alina1,Luo Hui2ORCID,Ramming Andreas1ORCID,Schett Georg1ORCID,Distler Oliver3ORCID,Distler Jörg H. W.1ORCID

Affiliation:

1. Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, Germany.

2. Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.

3. Center of Experimental Rheumatology and Zurich Center of Integrative Human Physiology, University Hospital Zurich, 8091 Zürich, Switzerland.

4. Department of Medicine, University of Pittsburgh, PA 15261, USA.

Abstract

Up-regulation of FGFR3 and FGF9 induces profibrotic pathways promoting fibroblast activation and tissue fibrosis in systemic sclerosis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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