ctDNA monitoring using patient-specific sequencing and integration of variant reads

Author:

Wan Jonathan C. M.12ORCID,Heider Katrin12ORCID,Gale Davina12ORCID,Murphy Suzanne123,Fisher Eyal12ORCID,Mouliere Florent124ORCID,Ruiz-Valdepenas Andrea12,Santonja Angela12ORCID,Morris James12,Chandrananda Dineika12ORCID,Marshall Andrea5ORCID,Gill Andrew B.236ORCID,Chan Pui Ying12ORCID,Barker Emily7ORCID,Young Gemma7,Cooper Wendy N.12ORCID,Hudecova Irena12ORCID,Marass Francesco12ORCID,Mair Richard128ORCID,Brindle Kevin M.129ORCID,Stewart Grant D.2310ORCID,Abraham Jean E.1112ORCID,Caldas Carlos1211ORCID,Rassl Doris M.213,Rintoul Robert C.21314,Alifrangis Constantine15ORCID,Middleton Mark R.16ORCID,Gallagher Ferdia A.234ORCID,Parkinson Christine3,Durrani Amer3,McDermott Ultan15ORCID,Smith Christopher G.12ORCID,Massie Charles1214ORCID,Corrie Pippa G.23ORCID,Rosenfeld Nitzan12ORCID

Affiliation:

1. Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

2. Cancer Research UK Major Centre—Cambridge, Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

3. Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.

4. Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Pathology, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, Netherlands.

5. Warwick Clinical Trials Unit, University of Warwick, Coventry CV4 7AL, UK.

6. Department of Radiology, University of Cambridge, Cambridge CB2 0QQ, UK.

7. Cambridge Clinical Trials Unit—Cancer Theme, Cambridge CB2 0QQ, UK.

8. Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.

9. Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK.

10. Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK.

11. Cambridge Breast Unit, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK.

12. Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge CB1 8RN, UK.

13. Royal Papworth Hospital NHS Foundation Trust, Cambridge CB2 0AY, UK.

14. Department of Oncology, University of Cambridge Hutchison–MRC Research Centre, Box 197, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK.

15. Wellcome Sanger Institute, Hinxton CB10 1SA, UK.

16. National Institute for Health Research Biomedical Research Centre, Oxford OX4 2PG, UK.

Abstract

Integration of variant reads across patient-specific mutation loci enables sensitive ctDNA quantification in plasma cell-free DNA sequencing data.

Funder

FP7 Ideas: European Research Council

Cancer Research UK

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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