Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer

Author:

Tie Jeanne1234,Wang Yuxuan5,Tomasetti Cristian67,Li Lu6,Springer Simeon5,Kinde Isaac8,Silliman Natalie5,Tacey Mark9,Wong Hui-Li134,Christie Michael1310,Kosmider Suzanne2,Skinner Iain2,Wong Rachel11112,Steel Malcolm11,Tran Ben1234,Desai Jayesh134,Jones Ian413,Haydon Andrew14,Hayes Theresa15,Price Tim J.16,Strausberg Robert L.17,Diaz Luis A.5,Papadopoulos Nickolas5,Kinzler Kenneth W.5,Vogelstein Bert5,Gibbs Peter123417

Affiliation:

1. Division of Systems Biology and Personalised Medicine, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.

2. Department of Medical Oncology, Western Health, St Albans, Victoria 3021, Australia.

3. Department of Medical Oncology,

4. Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria 3010, Australia.

5. Ludwig Center and Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287, USA.

6. Division of Biostatistics and Bioinformatics, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

7. Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

8. PapGene Inc., Baltimore, MD 21211, USA.

9. Melbourne EpiCentre, Department of Medicine, University of Melbourne, Parkville, Victoria 3010, Australia.

10. Department of Pathology, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia.

11. Department of Medical Oncology, Eastern Health, Box Hill, Victoria 3128, Australia.

12. Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria 3800, Australia.

13. Department of Surgery, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia.

14. Department of Medical Oncology, Alfred Hospital, Melbourne, Victoria 3004, Australia.

15. Department of Medical Oncology, Warrnambool Hospital, Warrnambool, Victoria 3280, Australia.

16. Department of Medical Oncology, Queen Elizabeth Hospital and University of Adelaide, Adelaide, South Australia 3174, Australia.

17. Ludwig Institute for Cancer Research, New York, NY 10017, USA.

Abstract

Detection of circulating tumor DNA in patients with resected stage II colon cancer provides evidence of residual disease.

Funder

Virginia and D.K. Ludwig Fund for Cancer Research

Conrad N. Hilton Foundation

Sol Goldman Sequencing Facility at Johns Hopkins

NIH

Victorian Cancer Agency

Victorian Cancer Agency Clinical Research Fellowship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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