A protective Langerhans cell–keratinocyte axis that is dysfunctional in photosensitivity-Reference-Cited by-同舟云学术

A protective Langerhans cell–keratinocyte axis that is dysfunctional in photosensitivity

Published:2018-08-15 Issue:454 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Shipman William D.¹²³^ORCID,Chyou Susan³^ORCID,Ramanathan Anusha³,Izmirly Peter M.⁴,Sharma Sneh⁵⁶,Pannellini Tania³,Dasoveanu Dragos C.³⁷,Qing Xiaoping³,Magro Cynthia M.⁸,Granstein Richard D.⁹^ORCID,Lowes Michelle A.¹⁰,Pamer Eric G.⁶^ORCID,Kaplan Daniel H.¹¹¹²^ORCID,Salmon Jane E.²³¹³¹⁴^ORCID,Mehrara Babak J.¹⁵,Young James W.⁵⁶¹⁰¹³¹⁶^ORCID,Clancy Robert M.⁴,Blobel Carl P.⁷¹³¹⁷¹⁸,Lu Theresa T.²³¹⁴¹⁹^ORCID

Affiliation:

1. Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program, New York, NY 10065, USA.

2. Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.

3. Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY 10021, USA.

4. Department of Medicine, New York University School of Medicine, New York, NY 10016, USA.

5. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

6. Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

7. Department of Physiology, Biophysics and Systems Biology, Weill Cornell Medicine, New York, NY 10065, USA.

8. Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA.

9. Department of Dermatology, Weill Cornell Medicine, New York, NY 10065, USA.

10. Rockefeller University, New York, NY 10065, USA.

11. Department of Dermatology, University of Pittsburgh, PA 15260, USA.

12. Department of Immunology, University of Pittsburgh, PA 15260, USA.

13. Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.

14. Division of Rheumatology and Pediatric Rheumatology, Hospital for Special Surgery, New York, NY 10021, USA.

15. Division of Plastic and Reconstructive Surgery, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

16. Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

17. Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA.

18. Institute for Advanced Studies, Technical University Munich, Munich, Germany.

19. Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10065, USA.

Abstract

Langerhans cells limit ultraviolet radiation–induced keratinocyte apoptosis and skin injury, and this axis is dysfunctional in lupus photosensitivity.

Funder

NIH Office of the Director

Lupus Research Institute

ST. GILES FOUNDATION

Alliance for Lupus Research

NIH

O’Neill Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference53 articles.