Affiliation:
1. Department of Dermatology Shanghai Institute of Dermatology Huashan Hospital Fudan University Shanghai P. R. China
2. Department of Dermatology Wuhan No. 1 Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan P. R. China
3. Hubei Province & Key Laboratory of Skin Infection and Immunity Wuhan P. R. China
4. Department of Allergy and Rheumatology Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs Hospital for Skin Diseases Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing P. R. China
Abstract
AbstractLangerhans cells (LCs) are the key antigen‐presenting cells in the epidermis in normal conditions and respond differentially to environmental and/or endogenous stimuli, exerting either proinflammatory or anti‐inflammatory effects. Current knowledge about LCs mainly originates from studies utilizing mouse models, whereas with the development of single‐cell techniques, there has been significant progress for human LCs, which has updated our understanding of the phenotype, ontogeny, differentiation regulation, and function of LCs. In this review, we delineated the progress of human LCs and summarized LCs’ function in inflammatory skin diseases, providing new ideas for precise regulation of LC function in the prevention and treatment of skin diseases.
Funder
National Natural Science Foundation of China