Thymidine phosphorylase exerts complex effects on bone resorption and formation in myeloma-Reference-Cited by-同舟云学术

Thymidine phosphorylase exerts complex effects on bone resorption and formation in myeloma

Published:2016-08-24 Issue:353 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Liu Huan¹,Liu Zhiqiang¹,Du Juan²,He Jin¹,Lin Pei³,Amini Behrang⁴,Starbuck Michael W.⁵,Novane Nora⁵,Shah Jatin J.¹,Davis Richard E.¹,Hou Jian²,Gagel Robert F.⁶,Yang Jing¹

Affiliation:

1. Department of Lymphoma and Myeloma, Division of Cancer Medicine, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

2. Department of Hematology, The Myeloma and Lymphoma Center, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China.

3. Department of Hematopathology, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

4. Department of Diagnostic Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

5. Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

6. Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Abstract

Myeloma-expressed thymidine phosphorylase enhances bone lesion formation by acting on osteoclasts and osteoblasts.

Funder

National Cancer Institute

National Cancer Institute UTMDACC SPORE in Multiple Myeloma Career Development Award

Developmental Research Program

American Cancer Society Research

University of Texas MD Anderson Cancer Center Institutional Research Grants Basic Research

Leukemia Research Foundation

American Society of Hematology

National Natural Science Foundation of China

Publisher