A validated gene regulatory network and GWAS identifies early regulators of T cell–associated diseases

Author:

Gustafsson Mika12,Gawel Danuta R.1,Alfredsson Lars3,Baranzini Sergio4,Björkander Janne5,Blomgran Robert6,Hellberg Sandra7,Eklund Daniel8,Ernerudh Jan78,Kockum Ingrid9,Konstantinell Aelita110,Lahesmaa Riita11,Lentini Antonio1,Liljenström H. Robert I.1,Mattson Lina1,Matussek Andreas5,Mellergård Johan12,Mendez Melissa13,Olsson Tomas9,Pujana Miguel A.14,Rasool Omid11,Serra-Musach Jordi14,Stenmarker Margaretha5,Tripathi Subhash11,Viitala Miro11,Wang Hui115,Zhang Huan1,Nestor Colm E.1,Benson Mikael1

Affiliation:

1. The Centre for Individualised Medicine, Department of Clinical and Experimental Medicine, Division of Pediatrics, Linköping University, SE-581 83 Linköping, Sweden.

2. Bioinformatics, Department of Physics, Chemistry, and Biology, Linköping University, SE-581 83 Linköping, Sweden.

3. Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Solna, Sweden.

4. Department of Neurology, University of California, San Francisco, CA 94158, USA.

5. Futurum-Academy for Health and Care, County Council of Jönköping, SE-551 85 Jönköping, Sweden.

6. Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine, Linköping University, SE-581 83 Linköping, Sweden.

7. Department of Clinical and Experimental Medicine, Division of Clinical Immunology, Unit of Autoimmunity and Immune Regulation, Linköping University, SE-581 83 Linköping, Sweden.

8. Department of Clinical Immunology and Transfusion Medicine, Linköping University, SE-581 83 Linköping, Sweden.

9. Department of Clinical Neurosciences, Karolinska Institutet and Centrum for Molecular Medicine, SE-171 77 Stockholm, Sweden.

10. Department of Medical Biology, The Arctic University of Norway, NO-9037 Tromsø, Norway.

11. Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, FI-20520 Turku, Finland.

12. Department of Neurology and Department of Clinical and Experimental Medicine, Linköping University, SE-581 83 Linköping, Sweden.

13. Laboratorio de Investigación en Enfermedades Infecciosas, LID, Universidad Peruana Cayetano Heredia, Lima PE-15102, Peru.

14. Program Against Cancer Therapeutic Resistance (ProCURE), Cancer and Systems Biology Unit, Catalan Institute of Oncology, IDIBELL, L’Hospitalet del Llobregat, ES-08908 Barcelona, Spain.

15. Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA.

Abstract

Combining a gene regulatory network and disease association data identified early regulators of T cell–associated diseases.

Funder

Generalitat de Catalunya AGAUR

Sigrid Juselius Foundation

Swedish Medical Research Council

Spanish Association Against Cancer

Spanish Ministry of Health ISCIII FIS

RTICC

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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