Restoring glucose uptake rescues neutrophil dysfunction and protects against systemic fungal infection in mouse models of kidney disease-Reference-Cited by-同舟云学术

Restoring glucose uptake rescues neutrophil dysfunction and protects against systemic fungal infection in mouse models of kidney disease

Published:2020-06-17 Issue:548 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Jawale Chetan V.¹^ORCID,Ramani Kritika¹,Li De-dong¹^ORCID,Coleman Bianca M.¹^ORCID,Oberoi Rohan S.¹^ORCID,Kupul Saran¹^ORCID,Lin Li¹,Desai Jigar V.²^ORCID,Delgoffe Greg M.³,Lionakis Michail S.²,Bender Filitsa H.⁴,Prokopienko Alexander J.⁵^ORCID,Nolin Thomas D.⁴⁵^ORCID,Gaffen Sarah L.¹^ORCID,Biswas Partha S.¹^ORCID

Affiliation:

1. Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.

2. Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20814, USA.

3. Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

4. Division of Renal-Electrolyte, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.

5. Department of Pharmacy and Therapeutics, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Abstract

Metabolic reprogramming with a GSK3β inhibitor corrects neutrophil dysfunction and improves antifungal function in mouse models of kidney disease.

Funder

National Institute of Allergy and Infectious Diseases

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference77 articles.

1. Nosocomial Bloodstream Infections in US Hospitals: Analysis of 24,179 Cases from a Prospective Nationwide Surveillance Study

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4. Clinical Outcomes of Dialysis Catheter–Related Candidemia in Hemodialysis Patients

5. Candida bloodstream infections in hemodialysis recipients

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