APOE genotype regulates pathology and disease progression in synucleinopathy-Reference-Cited by-同舟云学术

APOE genotype regulates pathology and disease progression in synucleinopathy

Published:2020-02-05 Issue:529 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Davis Albert A.¹²^ORCID,Inman Casey E.¹²^ORCID,Wargel Zachary M.¹²,Dube Umber¹³^ORCID,Freeberg Brittany M.¹²^ORCID,Galluppi Alexander¹²^ORCID,Haines Jessica N.¹²,Dhavale Dhruva D.¹²,Miller Rebecca¹²^ORCID,Choudhury Fahim A.¹²^ORCID,Sullivan Patrick M.⁴^ORCID,Cruchaga Carlos¹³^ORCID,Perlmutter Joel S.¹²⁵,Ulrich Jason D.¹²^ORCID,Benitez Bruno A.¹³^ORCID,Kotzbauer Paul T.¹²^ORCID,Holtzman David M.¹²⁶^ORCID

Affiliation:

1. Hope Center for Neurologic Disease, Washington University, St. Louis, MO 63110, USA.

2. Department of Neurology, Washington University, St. Louis, MO 63110, USA.

3. Department of Psychiatry, Washington University, St. Louis, MO 63110, USA.

4. Department of Medicine, Duke University Medical Center, Durham VAMC and Geriatric Research Clinical Center, Durham, NC 27705, USA.

5. Departments of Neuroscience and Radiology, Programs in Physical and Occupational Therapy, Washington University, St. Louis, MO 63110, USA.

6. Knight Alzheimer’s Disease Research Center, Washington University, St. Louis, MO 63110, USA.

Abstract

APOE genotype regulates disease development in mouse models of α-synucleinopathy and affects cognition in patients with Parkinson’s disease.

Funder

National Institutes of Health

the JPB Foundation

American Brain Foundation

American Academy of Neurology

BrightFocus Foundation

Mary E. Groff Surgical and Medical Research and Education Charitable Trust

Dobbins Family Fund

Barnes-Jewish Hospital Foundation

The Riney Foundation

The American Parkinson Disease Association

The Greater St. Louis Chapter of the APDA

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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