ICOSL + plasmacytoid dendritic cells as inducer of graft-versus-host disease, responsive to a dual ICOS/CD28 antagonist-Reference-Cited by-同舟云学术

ICOSL + plasmacytoid dendritic cells as inducer of graft-versus-host disease, responsive to a dual ICOS/CD28 antagonist

Published:2020-10-07 Issue:564 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Adom Djamilatou¹^ORCID,Dillon Stacey R.²^ORCID,Yang Jinfeng¹,Liu Hao¹,Ramadan Abdulraouf¹,Kushekhar Kushi¹,Hund Samantha¹^ORCID,Albright Amanda¹,Kirksey Maykala¹,Adeniyan Titilayo¹,Lewis Katherine E.²^ORCID,Evans Lawrence²^ORCID,Wu Rebecca²,Levin Steven D.²^ORCID,Mudri Sherri²^ORCID,Yang Jing²^ORCID,Rickel Erika²^ORCID,Seaberg Michelle²^ORCID,Henderson Katherine²,Gudgeon Chelsea J.²^ORCID,Wolfson Martin F.²,Swanson Ryan M.²^ORCID,Swiderek Kristine M.²^ORCID,Peng Stanford L.²^ORCID,Hippen Keli L.³^ORCID,Blazar Bruce R.³^ORCID,Paczesny Sophie¹⁴^ORCID

Affiliation:

1. Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

2. Alpine Immune Sciences, Seattle, WA 98102, USA.

3. Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA.

4. Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA.

Abstract

Intestinal CD146 + CCR5 + T cells activated by ICOSL + plasmacytoid DCs during acute GVHD can be inhibited by a dual ICOS/CD28 antagonist.

Funder

National Cancer Institute

National Institute of Allergy and Infectious Diseases

Leukemia and Lymphoma Society

National Heart Lung and Blood Institute