Targeted inhibition of PI3 kinase/mTOR specifically in fibrotic lung fibroblasts suppresses pulmonary fibrosis in experimental models-Reference-Cited by-同舟云学术

Targeted inhibition of PI3 kinase/mTOR specifically in fibrotic lung fibroblasts suppresses pulmonary fibrosis in experimental models

Published:2020-10-28 Issue:567 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Hettiarachchi Suraj U.¹^ORCID,Li Yen-Hsing¹,Roy Jyoti¹^ORCID,Zhang Fenghua¹,Puchulu-Campanella Estela¹^ORCID,Lindeman Spencer D.¹^ORCID,Srinivasarao Madduri¹^ORCID,Tsoyi Konstantin²³,Liang Xiaoliang²³,Ayaub Ehab A.²,Nickerson-Nutter Cheryl⁴,Rosas Ivan O.²³^ORCID,Low Philip S.¹^ORCID

Affiliation:

1. Department of Chemistry and Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA.

2. Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

3. Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

4. Three Lakes Foundation, Northbrook, IL 60062, USA.

Abstract

Inhibition of phosphatidylinositol 3-kinase in lung myofibroblasts reduced symptoms of IPF in rodents and in vitro human samples.

Funder

Hurvis Charitable Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference51 articles.

1. Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation

2. Therapy for Fibrotic Diseases: Nearing the Starting Line

3. Dissecting fibrosis: therapeutic insights from the small-molecule toolbox

4. Fibrosis imaging: Current concepts and future directions

5. At the frontiers of lung fibrosis therapy

Cited by 62 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Immune mechanisms and novel therapies for idiopathic pulmonary fibrosis;Pharmaceutical Science Advances;2024-12

2. Targeting the PI3K/mTOR pathway in idiopathic pulmonary fibrosis: Advances and therapeutic potential;Bioorganic & Medicinal Chemistry;2024-09

3. Efficacy and safety evaluation of cross-reactive Fibroblast activation protein scFv-based CAR-T cells;Frontiers in Immunology;2024-07-17

4. FAP Radioligand Linker Optimization Improves Tumor Dose and Tumor-to-Healthy Organ Ratios in 4T1 Syngeneic Model;Journal of Medicinal Chemistry;2024-07-16

5. Functional meniscus reconstruction with biological and biomechanical heterogeneities through topological self-induction of stem cells;Bioactive Materials;2024-06