Antigen-stimulated PBMC transcriptional protective signatures for malaria immunization-Reference-Cited by-同舟云学术

Antigen-stimulated PBMC transcriptional protective signatures for malaria immunization

Published:2020-05-13 Issue:543 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Moncunill Gemma¹²^ORCID,Scholzen Anja³^ORCID,Mpina Maximillian⁴⁵⁶^ORCID,Nhabomba Augusto²,Hounkpatin Aurore Bouyoukou⁷⁸,Osaba Lourdes⁹,Valls Raquel¹⁰,Campo Joseph J.¹²^ORCID,Sanz Hèctor¹,Jairoce Chenjerai²,Williams Nana Aba¹^ORCID,Pasini Erica M.¹¹,Arteta David⁹,Maynou Joan⁹,Palacios Lourdes⁹,Duran-Frigola Miquel¹²,Aponte John J.¹^ORCID,Kocken Clemens H. M.¹¹,Agnandji Selidji Todagbe⁷⁸,Mas José Manuel¹⁰,Mordmüller Benjamin⁸^ORCID,Daubenberger Claudia⁵⁶^ORCID,Sauerwein Robert³^ORCID,Dobaño Carlota¹²^ORCID

Affiliation:

1. ISGlobal, Hospital Clínic–Universitat de Barcelona, E-08036 Barcelona, Catalonia, Spain.

2. Centro de Investigação em Saúde de Manhiça (CISM), Rua 12, Cambeve, Vila de Manhiça, CP 1929 Maputo, Mozambique.

3. Department of Medical Microbiology, Radboud University Medical Center, 6500 HB Nijmegen, Netherlands.

4. Ifakara Health Institute, Bagamoyo Research and Training Centre. P.O. Box 74, Bagamoyo, Tanzania.

5. Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland.

6. University of Basel, Petersplatz 1, 4001 Basel, Switzerland.

7. Centre de Recherches Médicales de Lambaréné (CERMEL), BP 242 Lambaréné, Gabon.

8. Institute of Tropical Medicine and German Center for Infection Research, University of Tübingen, Wilhelmstraße 27, D-72074 Tübingen, Germany.

9. Progenika Biopharma. A Grifols Company, S.A., 48160 Derio, Vizcaya, Spain.

10. Anaxomics Biotech, S.L, 08008 Barcelona, Spain.

11. Department of Parasitology, Biomedical Primate Research Centre, Rijswijk, Netherlands.

12. Institute for Research in Biomedicine (IRB Barcelona). The Barcelona Institute of Science and Technology, 08028 Barcelona, Catalonia, Spain.

Abstract

Transcriptomic signatures before and after immunization predict protection against malaria induced by sporozoite and RTS,S/AS01E immunization.

Funder

PATH

FP7 Health

Netherlands Organisation for Health Research and Development

Agència de Gestió d’Ajuts Universitaris i de Recerca

Ministerio de Economía y Competitividad

Instituto de Salud Carlos III

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference133 articles.

1. WHO World Malaria Report 2019 (2019).

2. Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of March 2013 meeting

3. Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial

4. Malaria Vaccines: Recent Advances and New Horizons

5. Safety, Immunogenicity, and Protective Efficacy against Controlled Human Malaria Infection of Plasmodium falciparum Sporozoite Vaccine in Tanzanian Adults

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