Allergic asthma is distinguished by sensitivity of allergen-specific CD4 + T cells and airway structural cells to type 2 inflammation-Reference-Cited by-同舟云学术

Allergic asthma is distinguished by sensitivity of allergen-specific CD4 + T cells and airway structural cells to type 2 inflammation

Published:2016-10-05 Issue:359 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Cho Josalyn L.¹²,Ling Morris F.¹,Adams David C.²,Faustino Lucas¹,Islam Sabina A.¹,Afshar Roshi¹,Griffith Jason W.¹²,Harris Robert S.²,Ng Aylwin³⁴,Radicioni Giorgia⁵,Ford Amina A.⁵,Han Andre K.¹²,Xavier Ramnik³⁴,Kwok William W.⁶,Boucher Richard⁵,Moon James J.¹²,Hamilos Daniel L.¹,Kesimer Mehmet⁵,Suter Melissa J.²,Medoff Benjamin D.¹²,Luster Andrew D.¹

Affiliation:

1. Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

2. Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

3. Center for Computational and Integrative Biology and Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

4. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.

5. Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

6. Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA.

Abstract

The development of allergic asthma requires type 2 airway inflammation as well as increased sensitivity of airway epithelial cells and smooth muscle to inflammation.

Funder

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference51 articles.

1. Aeroallergen sensitization correlates with PC20 and exhaled nitric oxide in subjects with mild-to-moderate asthma

2. Allergic Rhinitis and Onset of Bronchial Hyperresponsiveness

3. Asthma and Allergic Inflammation

4. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma

5. The contribution of airway smooth muscle to airway narrowing and airway hyperresponsiveness in disease

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