Autoimmune manifestations in aged mice arise from early-life immune dysregulation

Author:

Mahmoud Tamer I.1,Wang Jingya1,Karnell Jodi L.1,Wang Qiming2,Wang Shu1,Naiman Brian1,Gross Phillip1,Brohawn Philip Z.3,Morehouse Chris3,Aoyama Jordan3,Wasserfall Clive4,Carter Laura1,Atkinson Mark A.4,Serreze David V.2,Braley-Mullen Helen5,Mustelin Tomas1,Kolbeck Roland1,Herbst Ronald1,Ettinger Rachel1

Affiliation:

1. Respiratory, Inflammation, and Autoimmunity Group, MedImmune LLC, Gaithersburg, MD 20878, USA.

2. The Jackson Laboratory, Bar Harbor, ME 04609, USA.

3. Translational Sciences–Pharmacogenomics, MedImmune LLC, Gaithersburg, MD 20878, USA.

4. Departments of Pathology and Pediatrics, University of Florida, Gainesville, FL 32610, USA.

5. Department of Medicine, University of Missouri, Columbia, MO 65212, USA.

Abstract

Autoimmune manifestations are driven by peripheral immune dysregulation in early life and are prevented by prophylactic targeting of the CD40/CD40L pathway.

Funder

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference80 articles.

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2. Serological implications of germinal center-like structures in primary Sjögren’s syndrome;Jonsson M. V.;J. Rheumatol.,2007

3. Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sjögren's syndrome

4. Molecular mechanism and function of CD40/CD40L engagement in the immune system

5. Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers;Han S.;J. Immunol.,1995

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