Autoimmune manifestations in aged mice arise from early-life immune dysregulation-Reference-Cited by-同舟云学术

Autoimmune manifestations in aged mice arise from early-life immune dysregulation

Published:2016-10-19 Issue:361 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Mahmoud Tamer I.¹,Wang Jingya¹,Karnell Jodi L.¹,Wang Qiming²,Wang Shu¹,Naiman Brian¹,Gross Phillip¹,Brohawn Philip Z.³,Morehouse Chris³,Aoyama Jordan³,Wasserfall Clive⁴,Carter Laura¹,Atkinson Mark A.⁴,Serreze David V.²,Braley-Mullen Helen⁵,Mustelin Tomas¹,Kolbeck Roland¹,Herbst Ronald¹,Ettinger Rachel¹

Affiliation:

1. Respiratory, Inflammation, and Autoimmunity Group, MedImmune LLC, Gaithersburg, MD 20878, USA.

2. The Jackson Laboratory, Bar Harbor, ME 04609, USA.

3. Translational Sciences–Pharmacogenomics, MedImmune LLC, Gaithersburg, MD 20878, USA.

4. Departments of Pathology and Pediatrics, University of Florida, Gainesville, FL 32610, USA.

5. Department of Medicine, University of Missouri, Columbia, MO 65212, USA.

Abstract

Autoimmune manifestations are driven by peripheral immune dysregulation in early life and are prevented by prophylactic targeting of the CD40/CD40L pathway.

Funder

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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5. Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers;Han S.;J. Immunol.,1995

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