The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity-Reference-Cited by-同舟云学术

The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity

Published:2016-11-16 Issue:365 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Wieczorek Michal¹,Tcherkezian Joseph²,Bernier Cynthia²,Prota Andrea E.³,Chaaban Sami¹,Rolland Yannève²,Godbout Claude²,Hancock Mark A.⁴,Arezzo Joseph C.⁵,Ocal Ozhan⁶,Rocha Cecilia¹,Olieric Natacha³,Hall Anita⁷⁸,Ding Hui⁹,Bramoullé Alexandre²,Annis Matthew G.⁷,Zogopoulos George⁷⁸,Harran Patrick G.⁹,Wilkie Thomas M.⁶,Brekken Rolf A.⁶,Siegel Peter M.⁷,Steinmetz Michel O.³,Shore Gordon C.²,Brouhard Gary J.¹,Roulston Anne²

Affiliation:

1. Department of Biology, McGill University, Montreal, Quebec H3A 1B1, Canada.

2. Laboratory for Therapeutic Development, Rosalind and Morris Goodman Cancer Research Centre and Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada.

3. Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institut, 5232 Villigen PSI, Switzerland.

4. McGill SPR-MS Facility, McGill University, Montreal, Quebec H3G 1Y6, Canada.

5. Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10561, USA.

6. Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA.

7. Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 1A3, Canada.

8. Research Institute of the McGill University Health Centre, Montreal, Quebec H4A 3J1, Canada.

9. Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095, USA.

Abstract

A compound that binds to tubulin in an unusual way has superior antitumor efficacy and safety and has a distinctive impact on microtubule curvature and dynamics.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference77 articles.

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5. The spindle checkpoint: structural insights into dynamic signalling

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