Affiliation:
1. Jiangsu Key Laboratory of Pesticide Science College of Sciences Nanjing Agricultural University Nanjing China
2. Department of Chemistry School of Applied Sciences Mongolian University of Life Sciences Ulaanbaatar Mongolia
3. National Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and Health Central China Normal University Wuhan China
4. Jealott's Hill International Research Centre Syngenta, Bracknell Berkshire UK
Abstract
Abstract5‐(3′‐Indolyl)oxazole moiety is a privileged heterocyclic scaffold, embedded in many biologically interesting natural products and potential therapeutic agents. Compounds containing this scaffold, whether from natural sources or synthesized, have demonstrated a wide array of biological activities. This has piqued the interest of synthetic chemists, leading to a large number of reported synthetic approaches to 5‐(3′‐indolyl)oxazole scaffold in recent years. In this review, we comprehensively overviewed the different biological activities and chemical synthetic methods for the 5‐(3′‐indolyl)oxazole scaffold reported in the literatures from 1963 to 2024. The focus of this study is to highlight the significance of 5‐(3′‐indolyl)oxazole derivatives as the lead compounds for the lead discovery of anticancer, pesticidal, antimicrobial, antiviral, antioxidant and anti‐inflammatory agents, to summarize the synthetic methods for the 5‐(3′‐indolyl)oxazole scaffold. In addition, the reported mechanism of action of 5‐(3′‐indolyl)oxazoles and advanced molecules studied in animal models are also reviewed. Furthermore, this review offers perspectives on how 5‐(3′‐indolyl)oxazole scaffold as a privileged structure might be exploited in the future.