Naturally acquired immunity against immature Plasmodium falciparum gametocytes

Author:

Dantzler Kathleen W.12ORCID,Ma Siyuan3,Ngotho Priscilla2ORCID,Stone Will J. R.45,Tao Dingyin67ORCID,Rijpma Sanna4ORCID,De Niz Mariana2,Nilsson Bark Sandra K.1,Jore Matthijs M.4,Raaijmakers Tonke K.4,Early Angela M.8,Ubaida-Mohien Ceereena9,Lemgruber Leandro2ORCID,Campo Joseph J.10ORCID,Teng Andy A.10,Le Timothy Q.10ORCID,Walker Cassidy L.10,Hermand Patricia11,Deterre Philippe11ORCID,Davies D. Huw12,Felgner Phil12,Morlais Isabelle13ORCID,Wirth Dyann F.1ORCID,Neafsey Daniel E.8,Dinglasan Rhoel R.614ORCID,Laufer Miriam15ORCID,Huttenhower Curtis3ORCID,Seydel Karl1617ORCID,Taylor Terrie1617,Bousema Teun45ORCID,Marti Matthias12

Affiliation:

1. Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

2. Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.

3. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

4. Radboud Institute for Health Sciences, Radboud University Medical Center, Netherlands.

5. Immunology and Infection Department, London School of Hygiene and Tropical Medicine, London, UK.

6. W. Harry Feinstone Department of Molecular Microbiology and Immunology and the Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

7. National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.

8. Broad Institute of Harvard and MIT, Cambridge, MA, USA.

9. National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.

10. Antigen Discovery Inc., Irvine, CA, USA.

11. Sorbonne Universités, UPMC Univ Paris 06, INSERM, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), UMR 1135, ERL CNRS 8255, F-75013 Paris, France.

12. Division of Infectious Diseases, Department of Medicine, University of California, Irvine, CA, USA.

13. UMR MIVEGEC UM1-CNRS 5290-IRD 224, Institut de Recherche pour le Développement, Montpellier Cedex, France.

14. Emerging Pathogens Institute, Department of Infectious Diseases and Immunology, University of Florida College of Veterinary Medicine, Gainesville, FL, USA.

15. Division of Malaria Research, Institute for Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.

16. Department of Osteopathic Medical Specialties, College of Osteopathic Medicine, Michigan State University, East Lansing, MI, USA.

17. Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi.

Abstract

Naturally acquired immune responses target infected red blood cell surface antigens of immature malaria transmission stages.

Funder

National Institute of Allergy and Infectious Diseases

Wellcome Trust

H2020 European Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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