Human genetics and neuropathology suggest a link between miR-218 and amyotrophic lateral sclerosis pathophysiology

Author:

Reichenstein Irit1ORCID,Eitan Chen12ORCID,Diaz-Garcia Sandra3ORCID,Haim Guy1,Magen Iddo1ORCID,Siany Aviad1ORCID,Hoye Mariah L.4ORCID,Rivkin Natali1,Olender Tsviya1ORCID,Toth Beata1ORCID,Ravid Revital1ORCID,Mandelbaum Amitai D.1ORCID,Yanowski Eran1ORCID,Liang Jing1ORCID,Rymer Jeffrey K.56ORCID,Levy Rivka7ORCID,Beck Gilad8ORCID,Ainbinder Elena8ORCID,Farhan Sali M. K.910ORCID,Lennox Kimberly A.11ORCID,Bode Nicole M.11ORCID,Behlke Mark A.11ORCID,Möller Thomas12ORCID,Saxena Smita1314ORCID,Moreno Cristiane A. M.15ORCID,Costaguta Giancarlo16,van Eijk Kristel R.217,Phatnani Hemali18ORCID,Al-Chalabi Ammar21920ORCID,Başak A. Nazli221,van den Berg Leonard H.217ORCID,Hardiman Orla22223ORCID,Landers John E.224ORCID,Mora Jesus S.225ORCID,Morrison Karen E.226ORCID,Shaw Pamela J.227ORCID,Veldink Jan H.217ORCID,Pfaff Samuel L.16ORCID,Yizhar Ofer7,Gross Christina56ORCID,Brown Robert H.28,Ravits John M.3ORCID,Harms Matthew B.15ORCID,Miller Timothy M.4ORCID,Hornstein Eran12ORCID

Affiliation:

1. Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.

2. Project MinE ALS Sequencing Consortium.

3. Department of Neurosciences, UC San Diego, La Jolla, CA 92093, USA.

4. Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.

5. Division of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.

6. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.

7. Department of Neurobiology, Weizmann Institute of Science, Rehovot 7610001, Israel.

8. Stem Cell Core and Advanced Cell Technologies Unit, Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot 7610001, Israel.

9. Analytic and Translational Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

10. Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

11. Integrated DNA Technologies, 1710 Commercial Park, Coralville, IA 52241, USA.

12. Department of Neurology, School of Medicine, University of Washington, Seattle, WA 98195, USA.

13. Department of Neurology, Inselspital University Hospital, University of Bern, Freiburgstrasse 16, CH-3010 Bern, Bern, Switzerland.

14. Department for BioMedical Research, University of Bern, Murtenstrasse 40, CH-3008 Bern, Switzerland.

15. Department of Neurology, Columbia University, New York, NY 10032, USA.

16. Gene Expression Laboratory and the Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

17. Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands.

18. Center for Genomics of Neurodegenerative Disease (CGND) and New York Genome Center (NYGC) ALS Consortium, New York, NY 10013, USA.

19. Maurice Wohl Clinical Neuroscience Institute and United Kingdom Dementia Research Institute, Department of Basic and Clinical Neuroscience, Department of Neurology, King’s College London, London SE5 9RX, UK.

20. Department of Neurology, King’s College Hospital, London SE5 9RS, UK.

21. Koç University Translational Medicine Research Center, NDAL, Istanbul 34010, Turkey.

22. Academic Unit of Neurology, Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin 2, Republic of Ireland.

23. Department of Neurology, Beaumont Hospital, Dublin 2, Republic of Ireland.

24. Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

25. ALS Unit, Hospital San Rafael, Madrid 28016, Spain.

26. Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK.

27. Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield S10 2HQ, UK.

28. Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

Abstract

Genetics, pathology, and molecular studies demonstrate that microRNA-218 is modulated and might play a role in amyotrophic lateral sclerosis.

Funder

Teva Pharmaceutical Industries

Legacy Heritage Fund

Target ALS

European Research Council

Minerva Foundation

Bruno and Ilse Frick Foundation for Research on ALS

NIH/NINDS

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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