Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure-Reference-Cited by-同舟云学术

Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure

Published:2015-12-18 Issue:6267 Volume:350 Page:1525-1529
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Amin Neal D.¹²³,Bai Ge¹,Klug Jason R.⁴,Bonanomi Dario¹,Pankratz Matthew T.¹,Gifford Wesley D.¹²⁵,Hinckley Christopher A.¹,Sternfeld Matthew J.¹⁶,Driscoll Shawn P.¹,Dominguez Bertha⁷,Lee Kuo-Fen⁷,Jin Xin⁴,Pfaff Samuel L.¹

Affiliation:

1. Howard Hughes Medical Institute and Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

2. Medical Scientist Training Program, University of California, San Diego (UCSD), 9500 Gilman Drive, La Jolla, CA 92037, USA.

3. Biomedical Sciences Graduate Program, UCSD, 9500 Gilman Drive, La Jolla, CA 92037, USA.

4. Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

5. Neurosciences Graduate Program, UCSD, 9500 Gilman Drive, La Jolla, CA 92037, USA.

6. Biological Sciences Graduate Program, UCSD, 9500 Gilman Drive, La Jolla, CA 92037, USA.

7. Peptide Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

Abstract

The makings of motor neuron disease Developing motor neurons link the muscles to the central nervous system. Amin et al. found that microRNA-218 (miR-218) was expressed in developing motor neurons and repressed a wide network of genes whose expression typifies other sorts of neurons. Mice lacking miR-218 died at birth with symptoms characteristic of human motor neuron diseases. Science , this issue p. 1525

Funder

Howard Hughes Medical Institute

National Cancer Institute

National Institute of Neurological Disorders and Stroke (NINDS)

NINDS

H.A. and Mary K. Chapman Charitable Foundation

Leona M. and Harry B. Helmsley Charitable Trust

UCSD Medical Scientist Training Program

Marshall Heritage Foundation

Sol Goldman Trust

The Clayton Foundation

Publisher