High-throughput sequencing of the T cell receptor β gene identifies aggressive early-stage mycosis fungoides

Author:

de Masson Adele1ORCID,O’Malley John T.1ORCID,Elco Christopher P.1,Garcia Sarah S.1,Divito Sherrie J.1ORCID,Lowry Elizabeth L.1ORCID,Tawa Marianne1,Fisher David C.2,Devlin Phillip M.3,Teague Jessica E.1,Leboeuf Nicole R.1,Kirsch Ilan R.4,Robins Harlan4ORCID,Clark Rachael A.1ORCID,Kupper Thomas S.1ORCID

Affiliation:

1. Department of Dermatology, Brigham and Women’s Hospital, and the Center for Cutaneous Oncology, Dana-Farber/Brigham and Women’s Cancer Center, Harvard Medical School, Boston, MA 02115, USA.

2. Center for Hematologic Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

3. Department of Radiation Oncology, Dana-Farber/Brigham and Women’s Cancer Center, Harvard Medical School, Boston, MA 02115, USA.

4. Adaptive Biotechnologies, Seattle, WA 98102, USA.

Abstract

The malignant T cell clone frequency in cutaneous T cell lymphoma lesions is an independent prognostic indicator for early disease progression and death.

Funder

NIH

NIAMS

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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