An optical nanoreporter of endolysosomal lipid accumulation reveals enduring effects of diet on hepatic macrophages in vivo

Author:

Galassi Thomas V.12ORCID,Jena Prakrit V.1ORCID,Shah Janki1,Ao Geyou3ORCID,Molitor Elizabeth4,Bram Yaron2ORCID,Frankel Angela2,Park Jiwoon2ORCID,Jessurun Jose2,Ory Daniel S.4,Haimovitz-Friedman Adriana1,Roxbury Daniel5,Mittal Jeetain6,Zheng Ming3,Schwartz Robert E.2,Heller Daniel A.12ORCID

Affiliation:

1. Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

2. Weill Cornell Medicine, New York, NY 10065, USA.

3. National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.

4. Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

5. Department of Chemical Engineering, University of Rhode Island, Kingston, RI 02881, USA

6. Department of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, PA 18015, USA.

Abstract

A nanoreporter noninvasively detects endolysosomal lipids, revealing that short-term changes in diet have enduring effects on hepatic macrophages.

Funder

National Science Foundation

National Institutes of Health

U.S. Department of Energy

American Cancer Society

Frank Lappin Horsfall Jr. Fellowship

Honorable Tina Brozman Foundation for Ovarian Cancer Research

The Anna Fuller Fund

The Frank A. Howard Scholars Program

The Alan and Sandra Gerry Metastasis Research Initiative

Ara Parseghian Medical Research Foundation

Pershing Square Foundation

Cycle for Survival

Cancer Center Support Grant

Expect Miracles Foundation - Financial Services Against Cancer

Louis V. Gerstner Jr. Young Investigator’s Fund

Mr. William H. Goodwin and Mrs. Alice Goodwin and the Commonwealth Foundation for Cancer Research

The Experimental Therapeutics Center

The Imaging & Radiation Sciences Program

The Center for Molecular Imaging and Nanotechnology of Memorial Sloan Kettering Cancer

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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