Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation-Reference-Cited by-同舟云学术

Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation

Published:2020-07-22 Issue:553 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Selvadurai Maria V.¹^ORCID,Moon Mitchell J.¹^ORCID,Mountford Simon J.²^ORCID,Ma Xiao²^ORCID,Zheng Zhaohua²,Jennings Ian G.²^ORCID,Setiabakti Natasha M.¹³^ORCID,Iman Rizani P.¹³,Brazilek Rose J.¹,Z. Abidin Nurul Aisha¹^ORCID,Chicanne Gaëtan⁴^ORCID,Severin Sonia⁴^ORCID,Nicholls Alyce J.⁵^ORCID,Wong Connie H.Y.⁵^ORCID,Rinckel Jean-Yves⁶,Eckly Anita⁶,Gachet Christian⁶^ORCID,Nesbitt Warwick S.¹⁷^ORCID,Thompson Philip E.²^ORCID,Hamilton Justin R.¹^ORCID

Affiliation:

1. Australian Centre for Blood Diseases, Monash University, Melbourne, VIC 3004, Australia.

2. Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.

3. Faculty of Medicine, Universitas Indonesia, Salemba, Jakarta 10430, Indonesia.

4. Institut des Maladies Métaboliques et Cardiovasculaires, Inserm U1048, Université Toulouse III, 31432 Toulouse CEDEX 4, France.

5. Centre for Inflammatory Diseases, Department of Medicine, Monash Medical Centre, Monash University, Clayton, VIC 3800, Australia.

6. Université de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S 1255, FMTS, F-67000 Strasbourg, France.

7. Microplatforms Research Group, School of Engineering, RMIT University, Melbourne, VIC 3000, Australia.

Abstract

First-generation PI3KC2α inhibitors prevent thrombosis without causing bleeding.

Funder

Australian Research Council

National Health and Medical Research Council

Cass Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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