Genetically modified lentiviruses that preserve microvascular function protect against late radiation damage in normal tissues-Reference-Cited by-同舟云学术

Genetically modified lentiviruses that preserve microvascular function protect against late radiation damage in normal tissues

Published:2018-01-24 Issue:425 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Khan Aadil A.¹²^ORCID,Paget James T.¹²^ORCID,McLaughlin Martin¹^ORCID,Kyula Joan N.¹^ORCID,Wilkinson Michelle J.¹,Pencavel Timothy¹,Mansfield David¹,Roulstone Victoria¹^ORCID,Seth Rohit¹,Halle Martin³⁴^ORCID,Somaiah Navita¹,Boult Jessica K. R.⁵^ORCID,Robinson Simon P.⁵^ORCID,Pandha Hardev S.⁶,Vile Richard G.⁷,Melcher Alan A.⁸^ORCID,Harris Paul A.²,Harrington Kevin J.¹

Affiliation:

1. Targeted Therapy Team, Division of Radiotherapy and Imaging, The Institute of Cancer Research, London SW3 6JB, UK.

2. Department of Plastic Surgery, The Royal Marsden Hospital, London SW3 6JJ, UK.

3. Department of Molecular Medicine and Surgery, Section of Plastic Surgery, Karolinska Institute, Stockholm 17176, Sweden.

4. Department of Reconstructive Plastic Surgery, Karolinska University Hospital, Stockholm 17176, Sweden.

5. Magnetic Resonance Team, Division of Radiotherapy and Imaging, The Institute of Cancer Research, London SM2 5NG, UK.

6. Postgraduate Medical School, University of Surrey, Guildford GU2 7XH, UK.

7. Molecular Medicine Program, Mayo Clinic, Rochester, MN 55905, USA.

8. Translational Immunotherapy Team, Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, SW3 6JB, UK.

Abstract

Vascular protection using gene therapy can reduce the late toxicities of radiotherapy.

Funder

Wellcome Trust

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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