Imageable Brachytherapy with Chelator‐Free Radiolabeling Hydrogel

Author:

Cui Zhencun123,Wang Liqin3,Liu Wei12,Xu Dan24,Zhang Taofeng5,Ma Baoliang3,Zhang Kai3,Yuan Lingyan4,Bing Zhitong4,Liu Jiangyan3,Liu Bin26ORCID,Wu Wangsuo12,Tian Longlong12ORCID

Affiliation:

1. MOE Frontiers Science Center for Rare Isotopes Lanzhou University 222 Tianshui South Road Lanzhou 730000 China

2. School of Nuclear Science and Technology Lanzhou University 222 Tianshui South Road Lanzhou 730000 China

3. Department of Nuclear Medicine Second Hospital of Lanzhou University 82 Cuiying Gate Lanzhou 730000 China

4. Key Laboratory of Heavy Ion Radiation Medicine Institute of Modern Physics Chinese Academy of Sciences 509 Nanchang Road Lanzhou 730000 China

5. School of Life Science and Engineering Lanzhou University of Technology 287 Langongping Road Lanzhou 730000 China

6. School of Stomatology Lanzhou University 199 Donggang West Road Lanzhou 730000 China

Abstract

AbstractBrachytherapy stands as an essential clinical approach for combating locally advanced tumors. Here, an injectable brachytherapy hydrogel is developed for the treatment of both local and metastatic tumor. Fe‐tannins nanoparticles are efficiently and stably radiolabeled with clinical used therapeutic radionuclides (such as 131I, 90Y, 177Lu, and 225Ac) without a chelator, and then chemically cross‐linked with 4‐armPEG‐SH to form brachytherapy hydrogel. Upon intratumoral administration, magnetic resonance imaging (MRI) signal from ferric ions embedded within the hydrogel directly correlates with the retention dosage of radionuclides, which can real‐time monitor radionuclides emitting short‐range rays in vivo without penetration limitation during brachytherapy. The hydrogel's design ensures the long‐term tumor retention of therapeutic radionuclides, leading to the effective eradication of local tumor. Furthermore, the radiolabeled hydrogel is integrated with an adjuvant to synergize with immune checkpoint blocking therapy, thereby activating potent anti‐tumor immune responses and inhibiting metastatic tumor growth. Therefore, this work presents an imageable brachytherapy hydrogel for real‐time monitoring therapeutic process, and expands the indications of brachytherapy from treatment of localized tumors to metastatic tumors.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Science and Technology Program of Gansu Province

Publisher

Wiley

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