Direct inhibitors of InhA are active against Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Direct inhibitors of InhA are active against Mycobacterium tuberculosis

Published:2015-01-07 Issue:269 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Manjunatha Ujjini H.¹²,S. Rao Srinivasa P.¹,Kondreddi Ravinder Reddy¹,Noble Christian G.¹,Camacho Luis R.¹,Tan Bee H.¹,Ng Seow H.¹,Ng Pearly Shuyi¹,Ma Ng L.¹,Lakshminarayana Suresh B.¹,Herve Maxime¹,Barnes Susan W.³,Yu Weixuan⁴,Kuhen Kelli³,Blasco Francesca¹,Beer David¹,Walker John R.³,Tonge Peter J.⁴,Glynne Richard³,Smith Paul W.¹,Diagana Thierry T.¹²

Affiliation:

1. Novartis Institute for Tropical Diseases, 138670 Singapore, Singapore.

2. Yong Loo Lin School of Medicine, National University of Singapore, 119228 Singapore, Singapore.

3. Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.

4. Institute of Chemical Biology & Drug Discovery, Stony Brook University, Stony Brook, NY 11794–3400, USA.

Abstract

4-Hydroxy-2-pyridones, direct inhibitors of the mycobacterial protein InhA, are active against multidrug-resistant Mycobacterium tuberculosis .

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference41 articles.

1. World Health Organization (WHO) Global Tuberculosis Report (WHO Press Geneva 2012); http://apps.who.int/iris/bitstream/10665/75938/1/9789241564502_eng.pdf.

2. Advances in the development of new tuberculosis drugs and treatment regimens

3. Single Nucleotide Polymorphisms in Genes Associated with Isoniazid Resistance in Mycobacterium tuberculosis

4. Encoded Library Technology as a Source of Hits for the Discovery and Lead Optimization of a Potent and Selective Class of Bactericidal Direct Inhibitors of Mycobacterium tuberculosis InhA

5. Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA

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