Encoded Library Technology as a Source of Hits for the Discovery and Lead Optimization of a Potent and Selective Class of Bactericidal Direct Inhibitors of Mycobacterium tuberculosis InhA-Reference-Cited by-同舟云学术

Encoded Library Technology as a Source of Hits for the Discovery and Lead Optimization of a Potent and Selective Class of Bactericidal Direct Inhibitors of Mycobacterium tuberculosis InhA

Published:2014-02-05 Issue:4 Volume:57 Page:1276-1288
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Encinas Lourdes¹,O’Keefe Heather²,Neu Margarete³,Remuiñán Modesto J.¹,Patel Amish M.²,Guardia Ana¹,Davie Christopher P.²,Pérez-Macías Natalia⁴,Yang Hongfang²,Convery Maire A.³,Messer Jeff A.²,Pérez-Herrán Esther¹,Centrella Paolo A.⁵,Álvarez-Gómez Daniel¹,Clark Matthew A.⁵,Huss Sophie¹,O’Donovan Gary K.²,Ortega-Muro Fátima¹,McDowell William⁶,Castañeda Pablo¹,Arico-Muendel Christopher C.²,Pajk Stane⁷,Rullás Joaquín¹,Angulo-Barturen Iñigo¹,Álvarez-Ruíz Emilio⁸,Mendoza-Losana Alfonso¹,Ballell Pages Lluís¹,Castro-Pichel Julia¹,Evindar Ghotas²

Affiliation:

1. Diseases of the Developing World, Tres Cantos Medicines Development Campus, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain

2. ELT Boston, Platform Technology & Science, GlaxoSmithKline, Waltham, Massachusetts 02451, United States

3. Computational and Structural Chemistry, Platform Technology & Science, GlaxoSmithKline, Stevenage SG1 2NY, Hertfordshire, U.K.

4. Instituto de Química Médica, Consejo Superior de Investigaciones Científicas (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain

5. X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States

6. Biological Reagent and Assay Development, Platform Technology & Science, GlaxoSmithKline, Stevenage SG1 2NY, Hertfordshire, U.K.

7. Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, SI-1000 Ljubljana, Slovenia

8. Centro de Investigación Básica, GlaxoSmithKline, 28760 Tres Cantos, Madrid, Spain

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm401326j

Reference42 articles.

1. Worldwide Incidence of Multidrug‐Resistant Tuberculosis

2. The global situation of MDR-TB

3. Epidemiology of antituberculosis drug resistance 2002–07: an updated analysis of the Global Project on Anti-Tuberculosis Drug Resistance Surveillance

4. Drug-resistant tuberculosis: Past, present, future

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