CRISPR-enhanced engineering of therapy-sensitive cancer cells for self-targeting of primary and metastatic tumors-Reference-Cited by-同舟云学术

CRISPR-enhanced engineering of therapy-sensitive cancer cells for self-targeting of primary and metastatic tumors

Published:2018-07-11 Issue:449 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Reinshagen Clemens¹²³^ORCID,Bhere Deepak¹²³^ORCID,Choi Sung Hugh¹²³,Hutten Stefan³,Nesterenko Irina³,Wakimoto Hiroaki¹²⁴^ORCID,Le Roux Eloi³^ORCID,Rizvi Alia³,Du Wanlu³^ORCID,Minicucci Charles³,Shah Khalid¹²³⁵

Affiliation:

1. Center for Stem Cell Therapeutics and Imaging, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

2. Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

3. Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

4. Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

5. Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.

Abstract

CRISPR-engineered receptor-specific self-targeted tumor cells demonstrate antitumor efficacy in vitro and in vivo.

Funder

James S. McDonnell Foundation

BWH Neurosurgery Departmental Funds

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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