Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis

Author:

Govaere Olivier1ORCID,Cockell Simon2ORCID,Tiniakos Dina13ORCID,Queen Rachel2ORCID,Younes Ramy14,Vacca Michele5ORCID,Alexander Leigh6ORCID,Ravaioli Federico17ORCID,Palmer Jeremy1,Petta Salvatore8,Boursier Jerome9,Rosso Chiara4ORCID,Johnson Katherine1ORCID,Wonders Kristy1,Day Christopher P.1,Ekstedt Mattias10ORCID,Orešič Matej11ORCID,Darlay Rebecca12,Cordell Heather J.12,Marra Fabio13ORCID,Vidal-Puig Antonio5ORCID,Bedossa Pierre114,Schattenberg Jörn M.15ORCID,Clément Karine16ORCID,Allison Michael17ORCID,Bugianesi Elisabetta4,Ratziu Vlad14,Daly Ann K.1ORCID,Anstee Quentin M.118ORCID

Affiliation:

1. Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

2. Bioinformatics Support Unit, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

3. Department of Pathology, Aretaieio Hospital, National and Kapodistrian University of Athens, 15771 Athens, Greece.

4. Department of Medical Sciences, Division of Gastro-Hepatology, A.O. Città della Salute e della Scienza di Torino, University of Turin, 10124 Turin, Italy.

5. University of Cambridge Metabolic Research Laboratories, Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 0QQ, UK.

6. SomaLogic Inc., Boulder, CO 80301, USA.

7. Department of Medical and Surgical Sciences, University of Bologna, 40126 Bologna, Italy.

8. Sezione di Gastroenterologia, Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, 90133 Palermo, Italy.

9. Hepatology Department, Angers University Hospital, 49933 Angers, France.

10. Department of Health, Medicine and Caring Sciences, Linköping University, 581 83 Linköping, Sweden.

11. School of Medical Sciences, Örebro University, 702 81 Örebro, Sweden.

12. Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

13. Dipartimento di Medicina Sperimentale e Clinica, University of Florence, 50121 Florence, Italy.

14. Assistance Publique–Hôpitaux de Paris, Hôpital Pitié Salpêtrière, Sorbonne University, ICAN (Institute of Cardiometabolism and Nutrition), 75013 Paris, France.

15. Department of Medicine, University Hospital Mainz, 55131 Mainz, Germany.

16. Nutrition and Obesities: Systemic Approaches, INSERM, Sorbonne University, 75006 Paris, France.

17. Liver Unit, Department of Medicine, NIHR Cambridge Biomedical Research Centre, Cambridge University NHS Foundation Trust, Cambridge CB2 0QQ, UK.

18. NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne NE7 7DN, UK.

Abstract

A 25-gene expression signature associates with progression of fibrosing steatohepatitis in independent NAFLD cohorts.

Funder

Horizon 2020 Framework Programme

Innovative Medicines Initiative

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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