Tau and other proteins found in Alzheimer’s disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans-Reference-Cited by-同舟云学术

Tau and other proteins found in Alzheimer’s disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans

Published:2020-11-25 Issue:571 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Simoes Sabrina¹^ORCID,Neufeld Jessica L.¹^ORCID,Triana-Baltzer Gallen²,Moughadam Setareh²,Chen Emily I.³,Kothiya Milankumar¹^ORCID,Qureshi Yasir H.¹,Patel Vivek¹^ORCID,Honig Lawrence S.¹⁴⁵^ORCID,Kolb Hartmuth²,Small Scott A.¹^ORCID

Affiliation:

1. Taub Institute for Research on Alzheimer’s Disease and the Aging Brain and the Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.

2. Neuroscience Biomarkers, Janssen Research and Development, San Diego, CA 92121, USA.

3. Thermo Fisher Precision Medicine Science Center, 790 Memorial Drive, Cambridge, MA 02139, USA.

4. Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.

5. Gertrude H. Sergievsky Center, Columbia University Irving Medical Center, New York, NY 10032, USA.

Abstract

Endosomal secreted proteins can be detected in the CSF and inform on how Alzheimer’s defective trafficking pathway can contribute to disease spread.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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5. Tau Kinetics in Neurons and the Human Central Nervous System

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