Metabolic regulation by PD-1 signaling promotes long-lived quiescent CD8 T cell memory in mice-Reference-Cited by-同舟云学术

Metabolic regulation by PD-1 signaling promotes long-lived quiescent CD8 T cell memory in mice

Published:2021-10-13 Issue:615 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Kalia Vandana¹²^ORCID,Yuzefpolskiy Yevgeniy²^ORCID,Vegaraju Adithya²,Xiao Hanxi²,Baumann Florian³,Jatav Shashank⁴^ORCID,Church Candice⁵^ORCID,Prlic Martin⁶⁷⁸^ORCID,Jha Abhishek⁴,Nghiem Paul⁵⁹^ORCID,Riddell Stanley⁹¹⁰^ORCID,Sarkar Surojit¹²⁷^ORCID

Affiliation:

1. Division of Hematology and Oncology, Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA.

2. Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute, Seattle, WA 98101, USA.

3. QIAGEN Sciences LLC, 19300 Germantown Rd, Germantown, MD 20874, USA.

4. Elucidata, Cambridge, MA 02139, USA.

5. Dermatology Division, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.

6. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

7. Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195, USA.

8. Department of Global Health, University of Washington School of Medicine, Seattle, WA 98195, USA.

9. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

10. Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.

Abstract

PD-1 signals promote development of long-lived quiescent memory CD8 T cells by regulating the balance of glycolysis and fatty acid oxidation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference94 articles.

1. Molecular and cellular insights into T cell exhaustion

2. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

3. Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

4. Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family

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