Paenibacillus infection with frequent viral coinfection contributes to postinfectious hydrocephalus in Ugandan infants

Author:

Paulson Joseph N.1ORCID,Williams Brent L.23ORCID,Hehnly Christine4,Mishra Nischay23ORCID,Sinnar Shamim A.56ORCID,Zhang Lijun4ORCID,Ssentongo Paddy578ORCID,Mbabazi-Kabachelor Edith9ORCID,Wijetunge Dona S. S.10,von Bredow Benjamin10ORCID,Mulondo Ronnie9,Kiwanuka Julius11,Bajunirwe Francis12ORCID,Bazira Joel13,Bebell Lisa M.14,Burgoine Kathy151617ORCID,Couto-Rodriguez Mara218ORCID,Ericson Jessica E.19ORCID,Erickson Tim9ORCID,Ferrari Matthew202122ORCID,Gladstone Melissa23ORCID,Guo Cheng2,Haran Murali22ORCID,Hornig Mady3ORCID,Isaacs Albert M.24ORCID,Kaaya Brian Nsubuga9ORCID,Kangere Sheila M.9ORCID,Kulkarni Abhaya V.25ORCID,Kumbakumba Elias11,Li Xiaoxiao23,Limbrick David D.26ORCID,Magombe Joshua9ORCID,Morton Sarah U.27ORCID,Mugamba John9,Ng James2,Olupot-Olupot Peter1628,Onen Justin9,Peterson Mallory R.57ORCID,Roy Farrah29,Sheldon Kathryn4ORCID,Townsend Reid30,Weeks Andrew D.31ORCID,Whalen Andrew J.32ORCID,Quackenbush John29ORCID,Ssenyonga Peter9,Galperin Michael Y.33ORCID,Almeida Mathieu34ORCID,Atkins Hannah35ORCID,Warf Benjamin C.36,Lipkin W. Ian23ORCID,Broach James R.4ORCID,Schiff Steven J.57203738

Affiliation:

1. Department of Biostatistics, Product Development, Genentech Inc., South San Francisco, CA 94080, USA.

2. Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.

3. Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA.

4. Institute for Personalized Medicine, Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

5. Center for Neural Engineering, Pennsylvania State University, University Park, PA 16802, USA.

6. Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

7. Department of Engineering Science and Mechanics, Pennsylvania State University, University Park, PA 16802, USA.

8. Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

9. CURE Children’s Hospital of Uganda, Plot 97-105, Bugwere Road, P.O. Box 903 Mbale, Uganda.

10. Department of Pathology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

11. Department of Pediatrics, Mbarara University of Science and Technology, P.O. Box 1410 Mbarara, Uganda.

12. Department of Epidemiology, Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda.

13. Department of Microbiology, Mbarara University of Science and Technology, P.O. Box 1410 Mbarara, Uganda.

14. Division of Infectious Disease, Massachusetts Genereal Hospital, Harvard Medical School, 55 Fruit St, GRJ-504, Boston, MA 02114, USA.

15. Neonatal Unit, Department of Paediatrics and Child Health, Mbale Regional Referral Hospital, Plot 29-33 Pallisa Road, P.O. Box 1966, Mbale, Uganda.

16. Mbale Clinical Research Institute, Mbale Regional Referral Hospital, Plot 29-33 Pallisa Road, P.O. Box 1966 Mbale, Uganda.

17. University of Liverpool, Liverpool, L69 3BX, UK.

18. Biotia, 100 6th avenue, New York, NY 10013, USA.

19. Division of Pediatric Infectious Disease, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

20. Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA 16802, USA.

21. Department of Biology, Pennsylvania State University, University Park, PA 16802, USA.

22. Department of Statistics, Pennsylvania State University, University Park, PA 16802, USA.

23. Institute for Translational Medicine, University of Liverpool, Liverpool, L12 2AP, UK.

24. Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63130, USA.

25. Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Toronto, Ontario, M5G 1X8, Canada.

26. Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63130, USA.

27. Division of Newborn Medicine, Boston Children’s Hospital and Department of Pediatrics, Harvard Medical School, Boston MA 02115, USA.

28. Busitema University, Mbale Campus, Plot 29-33 Pallisa Road, P.O. Box 1966, Mbale, Uganda.

29. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

30. Department of Medicine, Washington University School of Medicine , St. Louis, MO 63130, USA.

31. Sanyu Research Unit, Liverpool Women’s Hospital, University of Liverpool, Liverpool L8 7SS, UK.

32. Department of Mechanical Engineering, Pennsylvania State University, University Park, PA 16802, USA.

33. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.

34. Université Paris-Saclay, INRAE, MGP, Jouy-en-Josas, 78350, France.

35. Department of Comparative Medicine, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

36. Department of Neurosurgery, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

37. Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

38. Department of Physics, Pennsylvania State University, University Park, PA 16802, USA.

Abstract

A new strain of the bacterium Paenibacillus contributes to postinfectious hydrocephalus in Ugandan infants.

Funder

National Institutes of Health

NIH Office of the Director

National Center for Advancing Translational Sciences

NIH Intramural Research Program at the National Library of Medicine

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference100 articles.

1. Global hydrocephalus epidemiology and incidence: Systematic review and meta-analysis;Dewan M. C.;J. Neurosurg.,2018

2. Economic burden of neonatal sepsis in sub-Saharan Africa

3. Hydrocephalus in Uganda: The predominance of infectious origin and primary management with endoscopic third ventriculostomy;Warf B. C.;J. Neurosurg.,2005

4. Costs and benefits of neurosurgical intervention for infant hydrocephalus in sub-Saharan Africa

5. Hydrocephalus in the Sudan;Aziz I. A.;J. R. Coll. Surg. Edinb.,1976

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