The live attenuated dengue vaccine TV003 elicits complete protection against dengue in a human challenge model

Author:

Kirkpatrick Beth D.1,Whitehead Stephen S.2,Pierce Kristen K.1,Tibery Cecilia M.3,Grier Palmtama L.3,Hynes Noreen A.4,Larsson Catherine J.1,Sabundayo Beulah P.3,Talaat Kawsar R.3,Janiak Anna3,Carmolli Marya P.1,Luke Catherine J.4,Diehl Sean A.1,Durbin Anna P.3

Affiliation:

1. Vaccine Testing Center, Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05401, USA.

2. National Institutes of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.

3. Center for Immunization Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

4. Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

A controlled dengue human challenge model may determine whether to evaluate candidate dengue vaccines in large efficacy trials.

Funder

National Institutes of Allergy and Infectious Diseases Intramural Research Program

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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