Affiliation:
1. Wageningen University and Research, Laboratory of Virology, Wageningen, the Netherlands
Abstract
ABSTRACT
Live-attenuated flavivirus vaccines confer long-term protection against disease, but the design of attenuated flaviviruses does not follow a general approach. The non-coding, subgenomic flavivirus RNA (sfRNA) is produced by all flaviviruses and is an essential factor in viral pathogenesis and transmission. We argue that modulating sfRNA expression is a promising, universal strategy to finetune flavivirus attenuation for developing effective flavivirus vaccines of the future.
Funder
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Publisher
American Society for Microbiology
Cited by
1 articles.
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