Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration-Reference-Cited by-同舟云学术

Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration

Published:2016-08-17 Issue:352 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Fan Fuqin¹²,He Zhixiang¹²,Kong Lu-Lu³,Chen Qinghua¹²,Yuan Quan⁴,Zhang Shihao¹²,Ye Jinjin¹²,Liu Hao¹²,Sun Xiufeng¹²,Geng Jing¹²,Yuan Lunzhi⁴,Hong Lixin¹²,Xiao Chen¹²,Zhang Weiji¹²,Sun Xihuan¹²,Li Yunzhan¹²,Wang Ping¹²,Huang Lihong¹²,Wu Xinrui¹²,Ji Zhiliang¹²,Wu Qiao¹²,Xia Ning-Shao⁴,Gray Nathanael S.⁵,Chen Lanfen¹²,Yun Cai-Hong³,Deng Xianming¹²,Zhou Dawang¹²

Affiliation:

1. State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China.

2. State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, Xiamen University, Xiamen, Fujian 361102, China.

3. Institute of Systems Biomedicine, Department of Biophysics, and Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.

4. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, and School of Public Health, Xiamen University, Xiamen, Fujian 361102, China.

5. Department of Biological Chemistry and Molecular Pharmacology, and Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Longwood Center 2207, 360 Longwood Avenue, Boston, MA 02215, USA.

Abstract

Manipulation of the Hippo signaling pathway with a reversible and selective small-molecule inhibitor of Hippo kinase MST1/2 provides a therapeutic option for tissue injury and repair.

Funder

National Basic Research Program (973) of China

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities of China-Xiamen University

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference43 articles.

1. Wound repair and regeneration

2. Wound repair and regeneration: Mechanisms, signaling, and translation

3. Stem Cell Therapies in Clinical Trials: Progress and Challenges