Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration-Reference-Cited by-同舟云学术

Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration

Published:2015-06-12 Issue:6240 Volume:348 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zhang Yongyou¹,Desai Amar¹,Yang Sung Yeun¹²,Bae Ki Beom¹³,Antczak Monika I.⁴,Fink Stephen P.¹,Tiwari Shruti¹⁵,Willis Joseph E.⁵⁶⁷,Williams Noelle S.⁴,Dawson Dawn M.⁶⁷,Wald David⁵⁶⁷,Chen Wei-Dong¹,Wang Zhenghe⁶⁸,Kasturi Lakshmi¹,Larusch Gretchen A.¹,He Lucy¹,Cominelli Fabio¹⁵,Di Martino Luca¹,Djuric Zora⁹,Milne Ginger L.¹⁰,Chance Mark¹¹,Sanabria Juan⁵¹²,Dealwis Chris¹³,Mikkola Debra¹,Naidoo Jacinth⁴,Wei Shuguang⁴,Tai Hsin-Hsiung¹⁴,Gerson Stanton L.¹⁵⁶,Ready Joseph M.⁴¹⁵,Posner Bruce⁴¹⁵,Willson James K. V.¹⁵,Markowitz Sanford D.¹⁵⁶

Affiliation:

1. Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

2. Department of Gastroenterology, Haeundae Paik Hospital, Inje University, Busan 612896, South Korea.

3. Department of Surgery, Busan Paik Hospital, and Paik Institute of Clinical Research and Ocular Neovascular Research Center, Inje University, Busan, South Korea.

4. Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

5. Case Medical Center, University Hospitals of Cleveland, Cleveland, OH 44106, USA.

6. Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.

7. Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.

8. Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.

9. Department of Family Medicine, University of Michigan, Ann Arbor MI 48109, USA.

10. Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.

11. Proteomics Center, Case Western Reserve University, Cleveland, OH 44106, USA.

12. Department of Surgery, Case Western Reserve University, Cleveland, OH 44106, USA.

13. Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106, USA.

14. College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA.

15. Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Abstract

A shot in the arm for damaged tissue Tissue damage can be caused by injury, disease, and even certain medical treatments. There is great interest in identifying drugs that accelerate tissue regeneration and recovery, especially drugs that might benefit multiple organ systems. Zhang et al. describe a compound with this desired activity, at least in mice (see the Perspective by FitzGerald). SW033291 promotes recovery of the hematopoietic system after bone marrow transplantation, prevents the development of ulcerative colitis in the intestine, and accelerates liver regeneration after hepatic surgery. It acts by inhibiting an enzyme that degrades prostaglandins, lipid signaling molecules that have been implicated in tissue stem cell maintenance. Science , this issue 10.1126/science.aaa2340 ; see also p. 1208

Funder

NIH

Howard Hughes Medical Institute

Welch Foundation

Cancer Prevention Research Institute of Texas

National Research Foundation

Inje University

Harrington Discovery Institute

Marguerite Wilson Foundation

Ministry of Science, ICT and Future Planning of Korea

Leonard and Joan Horvitz Foundation

Richard Horvitz and Erica Hartman-Horvitz Foundation