Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal-Reference-Cited by-同舟云学术

Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

Published:2014-09-19 Issue:6203 Volume:345 Page:1509-1512
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Fares Iman¹,Chagraoui Jalila¹,Gareau Yves²,Gingras Stéphane²,Ruel Réjean²,Mayotte Nadine¹,Csaszar Elizabeth³,Knapp David J. H. F.⁴,Miller Paul⁴,Ngom Mor⁴,Imren Suzan⁴,Roy Denis-Claude⁵⁶,Watts Kori L.⁷,Kiem Hans-Peter⁷⁸,Herrington Robert⁹,Iscove Norman N.⁹¹⁰,Humphries R. Keith⁴,Eaves Connie J.⁴,Cohen Sandra⁵⁶,Marinier Anne²,Zandstra Peter W.³,Sauvageau Guy¹⁵⁶

Affiliation:

1. Molecular Genetics of Stem Cells Laboratory, Institute of Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, QC, Canada.

2. Medicinal Chemistry, IRIC, University of Montreal, Montreal, QC, Canada.

3. Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.

4. Terry Fox Laboratory, British Columbia Cancer Agency and University of British Columbia, Vancouver, BC, Canada.

5. Division of Hematology, Maisonneuve-Rosemont Hospital, Montreal, QC, Canada.

6. Department of Medicine, Faculty of Medicine, Université de Montreal, Montreal, QC, Canada.

7. Clinical Research Division, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA, USA.

8. Department of Medicine and Pathology, University of Washington, Seattle, WA, USA.

9. Ontario Cancer Institute, University Health Network, Toronto, ON, Canada.

10. Department of Immunology, University of Toronto, Toronto, ON, Canada.

Abstract

Human adult stem cell expansion Transfused blood saves lives. Despite the widespread use of this critical resource, it is difficult to increase blood cell numbers outside of the body. By screening thousands of small compounds, Fares et al. identify a molecule that expands human stem cell numbers in cord blood. The researchers generate many variations of that molecule and show that one such compound provides even greater human blood cell expansion. If researchers can provide increased numbers of stem cells and progenitor cells, cord blood should find even greater use in the clinic. Science , this issue p. 1509

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference19 articles.

1. HLA Match Likelihoods for Hematopoietic Stem-Cell Grafts in the U.S. Registry

2. Allogeneic hematopoietic cell transplantation for hematologic malignancy: relative risks and benefits of double umbilical cord blood

3. Transplants of Umbilical-Cord Blood or Bone Marrow from Unrelated Donors in Adults with Acute Leukemia

4. Heterogeneity in hematopoietic stem cell populations

5. Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice

Cited by 472 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Umbilical Cord Blood Hematopoietic Cells: From Biology to Hematopoietic Transplants and Cellular Therapies;Archives of Medical Research;2024-09

2. DNA-PK inhibition enhances gene editing efficiency in HSPCs for CRISPR-based treatment of X-linked hyper IgM syndrome;Molecular Therapy - Methods & Clinical Development;2024-09

3. Smarcd1 subunit of SWI/SNF chromatin-remodeling complexes collaborates with E2a to promote murine lymphoid specification;Developmental Cell;2024-09

4. Adaptation to ex vivo culture reduces human hematopoietic stem cell activity independently of the cell cycle;Blood;2024-08-15

5. Efficient generation of CAR NK cells from human umbilical cord blood CD34⁺stem and progenitors for democratizing affordable immunotherapy;2024-07-30