SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models-Reference-Cited by-同舟云学术

SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models

Published:2021-04-28 Issue:591 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Hyrenius-Wittsten Axel¹²^ORCID,Su Yang³,Park Minhee¹^ORCID,Garcia Julie M.¹^ORCID,Alavi Josef¹,Perry Nathaniel¹^ORCID,Montgomery Garrett¹^ORCID,Liu Bin²³⁴^ORCID,Roybal Kole T.¹²⁴⁵⁶^ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.

2. Parker Institute for Cancer Immunotherapy, San Francisco, CA 94143, USA.

3. Department of Anesthesia, University of California, San Francisco, San Francisco, CA 94110, USA.

4. Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.

5. Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.

6. Gladstone-UCSF Institute for Genomic Immunology, San Francisco, CA 94158, USA.

Abstract

SynNotch CAR circuits targeting specific solid tumor antigens enhance specificity and improve therapeutic efficacy by regulating T cell exhaustion.

Funder

National Cancer Institute

Parker Institute for Cancer Immunotherapy

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference50 articles.

1. Updates on CAR T-cell therapy in B-cell malignancies

2. Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

3. Chimeric antigen receptor T cell persistence and memory cell formation

4. Strategies to Address Chimeric Antigen Receptor Tonic Signaling

5. 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

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