4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors-Reference-Cited by-同舟云学术

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

Published:2015-05-04 Issue:6 Volume:21 Page:581-590
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Long Adrienne H,Haso Waleed M,Shern Jack F,Wanhainen Kelsey M,Murgai Meera,Ingaramo Maria,Smith Jillian P,Walker Alec J,Kohler M Eric,Venkateshwara Vikas R,Kaplan Rosandra N^ORCID,Patterson George H,Fry Terry J,Orentas Rimas J,Mackall Crystal L

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/nm.3838.pdf

Reference65 articles.

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3. Lee, D.W. et al. T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial. Lancet 385, 517–528 (2015).

4. Maude, S.L. et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. N. Engl. J. Med. 371, 1507–1517 (2014).

5. Kochenderfer, J.N. et al. B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor–transduced T cells. Blood 119, 2709–2720 (2012).

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