Losartan prevents tumor-induced hearing loss and augments radiation efficacy in NF2 schwannoma rodent models-Reference-Cited by-同舟云学术

Losartan prevents tumor-induced hearing loss and augments radiation efficacy in NF2 schwannoma rodent models

Published:2021-07-14 Issue:602 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Wu Limeng¹^ORCID,Vasilijic Sasa²^ORCID,Sun Yao¹^ORCID,Chen Jie¹^ORCID,Landegger Lukas D.²^ORCID,Zhang Yanling¹,Zhou Wenjianlong¹,Ren Jun¹^ORCID,Early Samuel²³,Yin Zhenzhen¹^ORCID,Ho William W.¹^ORCID,Zhang Na¹⁴^ORCID,Gao Xing¹^ORCID,Lee Grace Y.⁵^ORCID,Datta Meenal¹^ORCID,Sagers Jessica E.²^ORCID,Brown Alyssa²^ORCID,Muzikansky Alona⁶,Stemmer-Rachamimov Anat⁷^ORCID,Zhang Luo⁴^ORCID,Plotkin Scott R.⁸^ORCID,Jain Rakesh K.¹^ORCID,Stankovic Konstantina M.²^ORCID,Xu Lei¹^ORCID

Affiliation:

1. Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

2. Eaton-Peabody Laboratories and Department of Otolaryngology, Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA 02114, USA.

3. Division of Otolaryngology, Head and Neck Surgery, Department of Surgery, UC San Diego Medical Center, San Diego, CA 92103, USA.

4. Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing 100730, China.

5. St. Mark’s School, Southborough, MA 01772, USA.

6. Division of Biostatistics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

7. Molecular Pathology Division, Massachusetts General Hospital, Boston, MA 02114, USA.

8. Department of Neurology and Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA.

Abstract

Normalizing the tumor microenvironment with losartan prevents tumor-induced hearing loss and enhances radiation response in schwannoma rodent models.

Funder

U.S. Department of Defense

National Cancer Institute

National Institute on Deafness and Other Communication Disorders