Dynamic loading of human engineered heart tissue enhances contractile function and drives a desmosome-linked disease phenotype-Reference-Cited by-同舟云学术

Dynamic loading of human engineered heart tissue enhances contractile function and drives a desmosome-linked disease phenotype

Published:2021-07-21 Issue:603 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Bliley Jacqueline M.¹^ORCID,Vermeer Mathilde C. S. C.²^ORCID,Duffy Rebecca M.¹,Batalov Ivan¹^ORCID,Kramer Duco³^ORCID,Tashman Joshua W.¹^ORCID,Shiwarski Daniel J.¹^ORCID,Lee Andrew¹^ORCID,Teplenin Alexander S.⁴^ORCID,Volkers Linda⁴^ORCID,Coffin Brian⁵^ORCID,Hoes Martijn F.²^ORCID,Kalmykov Anna¹^ORCID,Palchesko Rachelle N.¹^ORCID,Sun Yan¹^ORCID,Jongbloed Jan D. H.⁶^ORCID,Bomer Nils²^ORCID,de Boer Rudolf A.²^ORCID,Suurmeijer Albert J. H.⁷,Pijnappels Daniel A.⁴^ORCID,Bolling Maria C.³,van der Meer Peter²^ORCID,Feinberg Adam W.¹⁵^ORCID

Affiliation:

1. Regenerative Biomaterials and Therapeutics Group, Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.

2. Department of Cardiology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.

3. Department of Dermatology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.

4. Department of Cardiology, Heart Lung Center Leiden, Leiden University Medical Center, 2333 ZA Leiden, Netherlands.

5. Department of Materials Science and Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.

6. Department of Genetics, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.

7. Department of Pathology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.

Abstract

A dynamic mechanical loading platform was developed to improve contractility of engineered heart tissues and study cardiac disease progression.

Funder

National Institutes of Health

Office of Naval Research

Carnegie Mellon University

H2020 European Research Council

Human Frontier Science Program

Additional Ventures Cures Collaborative

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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