Engineering sperm-binding IgG antibodies for the development of an effective nonhormonal female contraception

Author:

Shrestha Bhawana1ORCID,Schaefer Alison2,Zhu Yong3,Saada Jamal4ORCID,Jacobs Timothy M.56,Chavez Elizabeth C.7ORCID,Omsted Stuart S.8,Cruz-Teran Carlos A.5,Vaca Gabriela Baldeon9ORCID,Vincent Kathleen10ORCID,Moench Thomas R.81112,Lai Samuel K.12511ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

2. UNC/NCSU Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

3. Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.

4. Department of Ophthalmology, University of Texas Medical Branch, Galveston, TX 77555, USA.

5. Division of Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

6. Dualogics LLC, Durham, NC 27713, USA.

7. Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

8. Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA.

9. Divisions of Infectious Disease and Obstetrics & Gynecology, Boston University School of Medicine, Boston, MA 02118, USA.

10. Division of Gynecology, Department of Obstetrics and Gynecology, Center for Biomedical Engineering, University of Texas Medical Branch, Galveston, TX 77555, USA.

11. Mucommune LLC, Durham, NC 27709, USA.

12. Mapp Biopharmaceutical Inc., San Diego, CA 92121, USA.

Abstract

A panel of anti-sperm IgGs that effectively agglutinate human sperm in vitro and in sheep has been developed for nonhormonal contraception.

Funder

National Science Foundation

National Institutes of Health

PhRMA Foundation

David and Lucile Packard Foundation

Eshelman Institute for Innovation, University of North Carolina

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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